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Mikhail Akimov Selected Research

5- (2,4- dihydroxy- 5- isopropylphenyl)- 4- (4- morpholin- 4- ylmethylphenyl)isoxazole- 3- carboxylic acid ethylamide

1/2018Phase 2 Study of the HSP-90 Inhibitor AUY922 in Previously Treated and Molecularly Defined Patients with Advanced Non-Small Cell Lung Cancer.
10/2016Ocular toxicity of AUY922 in pigmented and albino rats.
6/2016Phase 1B/2 study of the HSP90 inhibitor AUY922 plus trastuzumab in metastatic HER2-positive breast cancer patients who have progressed on trastuzumab-based regimen.
7/2015Phase 1/1B trial of the heat shock protein 90 inhibitor NVP-AUY922 as monotherapy or in combination with bortezomib in patients with relapsed or refractory multiple myeloma.
9/2014Phase I dose-escalation study of the HSP90 inhibitor AUY922 in Japanese patients with advanced solid tumors.
8/201489Zr-trastuzumab and 89Zr-bevacizumab PET to evaluate the effect of the HSP90 inhibitor NVP-AUY922 in metastatic breast cancer patients.
7/2013First-in-human phase I dose-escalation study of the HSP90 inhibitor AUY922 in patients with advanced solid tumors.
4/2013Inhibition of HSP90 with AUY922 induces synergy in HER2-amplified trastuzumab-resistant breast and gastric cancer.

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Mikhail Akimov Research Topics

Disease

8Neoplasms (Cancer)
06/2022 - 07/2013
3Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2020 - 01/2018
3Nausea
11/2018 - 09/2014
3Breast Neoplasms (Breast Cancer)
06/2016 - 04/2013
3Diarrhea
06/2016 - 09/2014
2Lung Neoplasms (Lung Cancer)
11/2018 - 07/2013
2Toxic Optic Neuropathy
10/2016 - 07/2015
1Colorectal Neoplasms (Colorectal Cancer)
02/2020
1Edema (Dropsy)
11/2018
1Exanthema (Rash)
11/2018
1Disease Progression
11/2018
1Histiocytic Sarcoma
08/2015
1Multiple Myeloma
07/2015
1Night Blindness (Nyctalopia)
09/2014
1Stomach Neoplasms (Stomach Cancer)
04/2013

Drug/Important Bio-Agent (IBA)

85- (2,4- dihydroxy- 5- isopropylphenyl)- 4- (4- morpholin- 4- ylmethylphenyl)isoxazole- 3- carboxylic acid ethylamideIBA
01/2018 - 04/2013
4Pharmaceutical PreparationsIBA
11/2018 - 04/2013
3capmatinibIBA
02/2020 - 11/2018
2Trastuzumab (Herceptin)FDA Link
06/2016 - 04/2013
2Proteins (Proteins, Gene)FDA Link
08/2014 - 07/2013
1CarbamatesIBA
06/2022
1Capsules (Microcapsules)IBA
02/2020
1ErbB Receptors (EGF Receptor)IBA
11/2018
1Gefitinib (Iressa)FDA Link
11/2018
1Tyrosine Kinase InhibitorsIBA
11/2018
1AmylasesFDA Link
11/2018
1Lipase (Acid Lipase)FDA Link
11/2018
1Bortezomib (Velcade)FDA Link
07/2015
1Heat-Shock Proteins (Heat-Shock Protein)IBA
07/2015
189Zr-bevacizumabIBA
08/2014
1zirconium-89-trastuzumabIBA
08/2014
1Estrogen ReceptorsIBA
08/2014

Therapy/Procedure

6Therapeutics
06/2022 - 09/2014
1Drug Therapy (Chemotherapy)
06/2016